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KMID : 0358420050480030726
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Korean Journal of Obstetrics and Gynecology
2005 Volume.48 No. 3 p.726 ~ p.731
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CYP19 Gene Polymorphism in Patients with Endometriosis
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김진주/Kim JJ
최영민/허준용/구승엽/전종관/박성효/장은란/박노현/강순범/조수연/박인애/Choi YM/Hur JY/Ku SY/Jun JK/Park SH/Chang ER/Park NH/Kang SB/Cho SY/Park IA
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Abstract
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Objective: To explore the association of the CYP19 gene polymorphism with the risk of endometriosis.
Methods: Two hundred seventy-nine women with surgically or histologically diagnosed endometriosis of stages I-IV (ASRM, 1997) were recruited, and two hundred eighteen patients with no evidence of endometriosis by laparoscopy or laparotomy served as control. We analysed the frequency and distribution of a TTTA repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene.
Results: Six alleles of the CYP19 gene tetranucleotide repeat polymorphism were found in subjects: from 7 repeats to 13 repeats except 9 repeats. There was no statistically significant difference in the allele distribution of tetranucleotide repeat polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls. Also there was no statistically significant difference in the 3 bp insertion (I)/deletion (D) polymorphism in intron 4 of the CYP19 gene between patients with endometriosis and controls.
Conclusion: These results suggest that tetranucleotide repeat polymorphism and a 3 bp insertion (I)/deletion (D) polymorphism of the CYP19 gene are not associated with the risk endometriosis in the Korean population.
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